Journal: Scientific Reports

Article Title: Atypical age-related changes in cortical thickness in autism spectrum disorder

doi: 10.1038/s41598-020-67507-3

Figure Lengend Snippet: Developmental trajectories of CT for the hemispheric parcellation. The linear slope, curvature, and aberrancy from the three models (linear-top; quadratic-middle; cubic-bottom row) were estimated to quantify differences in age-related changes (trajectories) between ASD and TD. In the middle column, z-scores from the PLS analysis are plotted for the right and left hemisphere representing how reliable the model coefficients were in expressing the overall group differences. The trajectory shape represented by the curvature coefficient was most reliable, followed by the slope. In the trajectory sub-plots, red and blue lines represent the CT trajectories averaged across sub-groups, with the shade areas limited by their one standard deviation on each side. The points represent the individuals. CT measures are measured in millimeters (after removing the inter-center variability).

Article Snippet: To assess group differences in the slope, curvature, and aberrancy of the developmental trajectories in CT, as well as to test for their potential associations with ASD symptomatology, we applied Partial Least Squares (PLS) analysis using the PLS toolbox (available at: www.rotman-baycrest.on.ca/source/Pls.zip ) .

Techniques: Expressing, Standard Deviation